| Natural modulation of the gut microbiota in patients with pollen allergy. Impact of Alergiplant |
| Paper ID : 1315-IGA |
| Authors |
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Major Gheorghe GIURGIU *1, Med Manole COJOCARU2 1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania 2Academy of Romanian Scientists; Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania |
| Abstract |
| Background and Aim: A pollen allergy is a type of seasonal allergy triggered by pollen. A pollen allergy is sometimes known as seasonal allergic rhinitis. In a pollen allergy, immune system thinks pollen is a dangerous intruder, it produces an allergic reaction. Manipulation of gut microbial composition through the external intervention has initiated a new era in medical sciences, which could be a novel therapeutic approach for pollen allergy. Alergiplant could modulate the immune system through gut microbiota in pollen allergy. Advancing knowledge of the gut microbiome and its function in modulating the course of pollen allergy might result in novel therapeutic strategies. Methods: Pollen is one of the most common triggers of seasonal allergies. However, the precise mechanisms related to the effects of the microbiome on the pathogenesis of pollen allergy are unknown. We investigated the effect Alergiplant in patients with pollen allergy. Results: The pathogenesis of pollen allergy is complex and involves genetic, epigenetic, and environmental factors. In recent years, the gut microbiota has emerged as a significant contributor to the development of pollen allergy. Conclusion: The resident microbiota is important in maintaining structural and functional integrity of the gut and in immune system regulation. There was an increase of the gut permeability reported in patients with pollen allergy and a reduction of the gut microbiome diversity. Modifying gut microbiome by applying Alergiplant during early years may be a preventive and therapeutic option in high risk groups. |
| Keywords |
| Pollen allergy, Host-microbiome interaction, Immune regulation, Alergiplant |
| Status: Accepted |
