| Assessment of the Hemostatic and Wound Healing Properties of Heliotropium europaeum |
| Paper ID : 1300-IGA |
| Authors |
|
Dorsaf Moalla Rekik * Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Tunisia |
| Abstract |
| Abstract Background and Aim: This study aimed to rigorously evaluate the in vivo wound healing and hemostatic properties of Heliotropium europaeum (heliotrope), leveraging its documented antioxidant activity. A standardized excision wound model was employed in rats, creating uniform superficial wounds. Materials and Methods: These were treated topically with a hydroalcoholic extract of heliotrope, with healing progression compared against a negative control and a marketed reference product. Parameters measured included wound contraction rate, epithelialization period, and histopathological analysis. Results: The heliotrope extract demonstrated immediate hemostatic action, significantly reducing bleeding time upon application. Furthermore, it accelerated wound closure, achieving complete epithelialization faster than both the control and the reference product. This enhanced efficacy is attributed to a synergistic combination of the plant's bioactive constituents, which likely promote coagulation, scavenge free radicals, and inhibit microbial growth. Conclusion: These findings robustly confirm the pharmacological potential of H. europaeum for developing advanced dermatological applications, including therapeutic wound care agents and regenerative cosmetic products. |
| Keywords |
| Heliotropium europaeum; hemostatic; wound healing; properties |
| Status: Accepted |
