| Advances and Challenges in Precision Medicine: Translational Approaches and Network Oncology Perspectives from Italian Research Initiatives |
| Paper ID : 1297-IGA |
| Authors |
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Masoumeh Aalipour * Department of Cell and Molecular Biology, Ashrafi Isfahani University, Isfahan, Iran |
| Abstract |
| Background and Aim: Precision medicine, integrating genomic, molecular, and clinical data, has transformed personalized healthcare strategies. This review aims to synthesize recent advances and challenges in translational approaches and network oncology within precision medicine as pursued in Italian research contexts. Methods: A structured literature search was performed using databases such as PubMed, Scopus, and Google Scholar from 2020 to 2025. AI-assisted tools supported screening and analysis. Key terms included "precision medicine," "translational research," "network oncology," "Italy," and related synonyms. Inclusion criteria prioritized original research, clinical trials, and reviews focusing on translational and network-based oncology approaches in precision medicine. Articles not in English or not aligned with the thematic scope were excluded. Results: The study results exhibit significant progress in the implementation of multi-omics data integration, biomarker discovery, and patient stratification models in Italian research contexts. Although improved network oncology approaches have facilitated understanding of tumor heterogeneity and therapeutic resistance, significant challenges remain in data standardization, interdisciplinary collaboration, and equitable clinical translation. Conclusion: Research in Italian academia have contributed significantly to advancing precision medicine, particularly through translational and network oncology frameworks. Addressing existing challenges can enhance the clinical impact and foster broader adoption of precision strategies. Meanwhile, more research are required to emphasize integrative analytics and collaborative infrastructures to enhance personalized cancer treatment and care. |
| Keywords |
| Precision medicine, Translational research, Network oncology, Biomarkers, Personalized therapy |
| Status: Accepted |
