| Protective Effect of Vitamin E on Testicular Gland and Serum Testosterone Levels in Adult Male Rats Treated with Hydroalcoholic Extract of Vitis vinifera Leaves |
| Paper ID : 1296-IGA |
| Authors |
|
Rezvaneh Jahangiri * Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran |
| Abstract |
| Background and Aim: Grapevine leaves (Vitis vinifera), due to their polyphenolic compounds and antioxidant properties, may influence the reproductive system. Vitamin E, with its strong antioxidant capacity, plays a significant protective role in reproductive gland function. This study aimed to investigate the protective effect of vitamin E on the testicular glands and serum testosterone levels in adult male rats treated with hydroalcoholic extract of grapevine leaves. Methods: In this experimental study, 36 adult male Wistar rats were randomly divided into control, grapevine leaf extract (200 and 400 mg/kg), vitamin E (5 mg/kg), and two combination groups receiving both vitamin E and the extract at either dose. Treatments were administered for 28 days and at the end of the study, body weight, testis weight, and serum testosterone levels were measured. Data were analyzed using one-way ANOVA. Results: Treatment with grapevine leaf extract at both doses significantly reduced body weight and serum testosterone levels compared to the control group (P<0.05). Co-administration of vitamin E and the extract showed a partial improvement in body weight and testosterone levels but did not return to control levels. Vitamin E alone significantly increased serum testosterone levels compared to the control and extract-treated groups (P<0.05). No significant difference was observed in testis weight among the groups. Conclusion: Vitamin E, due to its antioxidant properties, can partially mitigate the adverse effects of grapevine leaf extract. However, simultaneous administration of the two substances may negatively affect testosterone production, suggesting the need for further investigation. |
| Keywords |
| Grape leaf, Vitamin E, Testosterone, Hydroalcoholic extract, Adult male rat |
| Status: Accepted |
