| Advances in Selenium Nanoparticles for Targeted Cancer Therapy: Mechanisms and Clinical Potential |
| Paper ID : 1292-IGA |
| Authors |
|
Tahereh Ghaderi * Affiliation |
| Abstract |
| Background and Aim: Since cancer continues to be a major cause of death globally, new therapeutic approaches are required. Because of their distinct physicochemical characteristics, biocompatibility, and anticancer potential, selenium nanoparticles (SeNPs) have become highly promising agents. A thorough synthesis of current developments addressing their processes and therapeutic applicability is absent, despite increased interest. In order to inform future research, this review attempts to objectively assess the advancements made in SeNP-based targeted cancer therapeutics, clarify their underlying mechanisms, and investigate their clinical potential. Methods: Using databases like PubMed, Scopus, and Web of Science, together with AI-assisted screening methods, a thorough literature search was carried out. Important phrases like "anticancer mechanisms," "cancer therapy," "targeted treatment," and "selenium nanoparticles" were used. Peer-reviewed publications published in English between 2020 and the present were the main focus of the search approach. Relevance to SeNP synthesis, anticancer efficacy, targeted administration methods, and preclinical or clinical results were taken into consideration while choosing studies. Results: According to recent research, SeNPs selectively kill cancer cells by triggering apoptosis, producing reactive oxygen species, and altering signaling pathways. Surface functionalization decreases off-target effects while improving targeted delivery. Preclinical models show good safety profiles and a notable reduction of tumor development. Clinical evidence is still scarce, though, which emphasizes the necessity of more translational research. Conclusion: With their strong mechanistic effects and possible therapeutic advantages, selenium nanoparticles offer a promising new avenue for targeted cancer treatment. To fully realize their medicinal potential, more research into improving delivery methods and conducting reliable clinical studies is necessary. |
| Keywords |
| Selenium nanoparticles, Targeted cancer therapy, Anticancer mechanisms, Nanomedicine, Drug delivery systems |
| Status: Accepted |
