| Stem Cells in Personalized Tissue Engineering |
| Paper ID : 1291-IGA |
| Authors |
|
Mehrnoush Ebadi * Department of engineering, bioengineering campus, University of Genova, Italy |
| Abstract |
| Background and Aim: Over the past ten years, tissue engineering has made great progress, and stem cells are essential for the regeneration and repair of damaged tissues. Customizing regeneration techniques for each patient through personalized tissue engineering has enormous potential to enhance clinical results. However, because of differences in cell activity, scaffold compatibility, and immune response, there are still difficulties in converting stem cell therapies into customized solutions. The purpose of this review is to examine the function of stem cells in customized tissue engineering and evaluate current developments, significant obstacles, and potential future paths. Methods: Web of Science, PubMed, and Scopus databases were used to do a systematic literature review. "Stem cells," "individualized tissue engineering," "regenerative medicine," "biomaterials," and "patient-specific scaffolds" were among the keywords. Included were articles written in English and released between 2020 and 2025. Relevance to patient-specific modeling, scaffold design, therapeutic applications, and stem cell sources were taken into consideration while choosing studies. AI-based methods for patient assessment and design optimization were also taken into account. Results: Recent research shows that mesenchymal stem cells, induced pluripotent stem cells, and embryonic stem cells can all be used to create tissues that are unique to each patient. The accuracy and versatility of synthetic tissues have increased thanks to developments in 3D bioprinting, computational modeling, and AI-assisted scaffold design. Long-term integration, vascularization, and immunological tolerance are still difficult to achieve despite advancements. Conclusion: The future of customized tissue engineering depends heavily on stem cells. The development of customized regenerative therapies is being accelerated by integration with AI-driven technologies and biomaterial innovation, opening the door to more efficient and customized patient care. |
| Keywords |
| Stem Cells, Personalized Tissue Engineering, Regenerative Medicine, Biomaterials, 3D Bioprinting |
| Status: Accepted |
