| Green Chemistry Approaches to Synthesize Biocompatible Nanoparticles for Biomedical Applications |
| Paper ID : 1284-IGA |
| Authors |
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Atefeh Hasanli * Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran |
| Abstract |
| Background and Aim: The synthesis of biocompatible nanoparticles via green chemistry has gained significant attention due to its eco-friendly and biologically safe nature, providing sustainable alternatives to conventional chemical methods. This review aims to systematically explore recent advancements in green synthesis strategies using biological agents such as plants and microorganisms, highlighting their potential in biomedical applications. Methods: A comprehensive literature review was conducted focusing on studies published over the last decade that describe nanoparticle synthesis using plant extracts, microbial cultures, and biomolecules. Emphasis was placed on control of nanoparticle physicochemical properties, biocompatibility, functionalization, and application in diagnostics, drug delivery, and therapeutics. Results: Green synthesis methods utilize plant phytochemicals and microbial enzymes to reduce metal ions, yielding nanoparticles with controlled size, shape, and functional properties. Plant-based extracts are cost-effective, biocompatible, and offer additional bioactive functionalities, enhancing therapeutic potential. Microbial exopolysaccharides provide stabilization and surface modification capabilities. Applications span antibacterial agents, imaging, theranostics, and drug delivery systems. Biocompatibility and reduced cytotoxicity are critical benefits over chemically synthesized nanoparticles. Conclusion: Green chemistry provides sustainable, efficient pathways for synthesizing biocompatible nanoparticles with versatile biomedical applications. However, challenges remain in large-scale production, precise control over nanoparticle morphology, and detailed pharmacokinetic and toxicity assessments. Ongoing research integrating green synthesis with nanotechnology promises advanced, safer nanomaterials for future biomedical innovations. |
| Keywords |
| Green synthesis, Biocompatible nanoparticles, Plant extracts, Microbial synthesis, Drug delivery, Theranostics, Nanobiotechnology, Biomedical applications |
| Status: Accepted |
