| Smart Nanomaterials for Targeted Drug Delivery and Controlled Release in Cancer Therapy |
| Paper ID : 1283-IGA |
| Authors |
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Atefeh Hasanli * Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran |
| Abstract |
| Background and Aim: The development of smart nanomaterials for targeted drug delivery and controlled release in cancer therapy has emerged as a critical strategy to enhance therapeutic efficacy while reducing systemic toxicity. This review aims to examine the advancements in nanocarrier systems, including mesoporous silica nanoparticles, magnetic nanocomposites, liposomes, micelles, dendrimers, and nucleic acid-based nanostructures, focusing on their stimuli-responsive mechanisms and targeting capabilities. Methods: A comprehensive literature survey was conducted analyzing recent studies on smart nanomaterials designed for cancer therapy. The review emphasizes design strategies for stimuli-responsive drug release, multifunctionality, and tumor microenvironment targeting, integrating knowledge from polymer science, nanotechnology, and molecular biology. Results: Mesoporous silica nanoparticles showcase tunable pore structures facilitating controlled drug release and prevention of premature release. Magnetic nanocomposites combine hyperthermia with pH- and thermo-responsive delivery, enabling external manipulation of drug release. Stimuli-responsive surface modifications, such as light-triggered wettability changes, provide spatial and temporal control. Co-delivery systems enhance efficacy by targeting multiple pathways, with polymer scaffolds supporting sustained localized delivery. Additionally, DNA nanomaterials enable precision gene therapy through disassembly triggered by cellular cues. Conclusion: The convergence of stimuli-responsive design, multifunctionality, and precise targeting in smart nanomaterials presents promising advances for cancer therapy. Tailoring nanocarrier properties to exploit tumor microenvironment conditions and external stimuli enhances drug delivery precision and safety. Future research should aim to optimize scalability, biocompatibility, and clinical translation. |
| Keywords |
| Smart nanomaterials, Targeted drug delivery, Controlled release, Cancer therapy, Mesoporous silica nanoparticles, Magnetic nanocomposites, Stimuli-responsive, Nanotheranostics, Polymer scaffolds, DNA nanomaterials |
| Status: Accepted |
