| ANALYSIS OF MDR1 POLYMORPHISM İN ALGERİAN PATIENTS WITH RHEUMATIC PELVISPONDYLITIS |
| Paper ID : 1270-IGA |
| Authors |
|
ASMAA AZZOUNE *1, CHAHINEZ AMIRA DAHMANI2 11- Higher School of Biological Sciences of Oran (ESSBO) 2- Molecular and Cellular Genetics Laboratory/University of Science and Technology of Oran Mohamed Boudiaf (USTO‐MB), El Mnouar, BP 1505, Bir El Djir, 31000, Oran, Algeria. 2Abdelhamid Ibn Badis Mostaganem University (UMAB), Algeria. |
| Abstract |
| Introduction and Purpose: Rheumatic Pelvispondylitis (RP), is believed to be the leader in a group of chronic inflammatory rheumatism commonly referred to as spondyloarthropathies. The present work consisted of exploring the association relationship that can exist between MDR1 C3435T polymorphism and the predisposition to Rheumatic Pelvispondylitis (RP) in the Algerian population. We compared the frequency of this polymorphism between the group of RP and healthy subjects Materials and Methods: A case-control study involving 81 RP patients and 98 controls was conducted. DNA genotyping was done using predesigned probe-based allelic discrimination TaqMan® assays. Allele and genotype frequencies were compared between cases and controls and Statistical analyses were performed with SAS software (version 9.1, SAS institute Inc., Cary NC). Results: No statistically significant differences were observed in the frequencies of MDR1 genotypes and alleles between RP cases and the control group. In contrast, the recessif model (CC+CT/TT) (OR=8.99 [11.97-40.99], p = 0.004) was significantly associated with mixte form of the disease, and the heterozygote genotype 3435CT protect from Axiel form. Moreover, a positive association was also founded between the MDR1 C3435T polymorphism and BMI (OR: 5.19[1.41-19.9], p = 0.01). Discussion and Conclusion: Results on the association of MDR1 polymorphisms with susceptibility to ankylosing spondylitis are obtained for the first time in an Algerian population. They imply that the MDR1 C3435T SNP do not affect the risk of RP, but rather the form of the disease and BMI. |
| Keywords |
| Algerian population, Rheumatic Pelvispondylitis, MDR1, C3435T |
| Status: Accepted |
