| Antioxidant, antihemolytic, antithrombotic and anti-inflammatory activity of seed extracts from Styphnolobium japonicum |
| Paper ID : 1266-IGA |
| Authors |
|
Karima Saffidine * Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University Setif1
Ferhat Abbas, Setif 19000, Algeria. |
| Abstract |
| Background and Aim: Antioxidants can prevent or treat diseases linked to oxidative stress. Research on medicinal plants known for their benefits effect to protect human health has increased as a result of the search for more potent alternatives to synthetic antioxidants. In this context, our study was undertaken to assess biological properties of Styphnolobium japonicum used in traditional medicine to treat many diseases. Material and methods: The aim of this work was to estimate the total phenolic (TPC), flavonoids (TFC) content and tannins of seed extracts: crude extract (CrES), ethyl acetate (EAES) and aqueous (AqES) fractions; as well their antioxidant, antihemolytic, antithrombotic and anti-inflammatory activity. Results: The results showed that EAES has the highest amounts of TPC, TFC and Tannins. Antioxidant potential of different extracts has been investigated in vitro using several methods. EAES possesses the strongest antioxidant capacity in scavenging ABTS and hydrogen peroxide free radicals, reducing power activity and has the ability to inhibit the hemolysis of red blood cells. All extracts prevent blood clotting even after three hours at doses 50 and 100 mg/ml; and have significant thrombolytic activity. Moreover, the anti-inflammatory potential of different extracts was evaluated using the inhibition of albumin denaturation test at a concentration of 2, 1, 0.5 and 0.25 mg/mL. This anti-inflammatory activity was dose-dependent and was significant for EAES and CrES. Conclusion: These results demonstrate Styphnolobium Japonicum species’ potential as a valuable source of bioactive chemicals with strong antioxidant and anti-inflammatory properties, and support its traditional use in treating various diseases. |
| Keywords |
| Styphnolobium japonicum, polyphenols, flavonoids, antioxidant, anti-thrombotic, anti-inflammatory activity |
| Status: Accepted |
