| Modulating Hebbian Plasticity via Multi-Site Non-Invasive Brain Stimulation: Implications for Cognitive and Affective Network Functions |
| Paper ID : 1262-IGA |
| Authors |
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Sogol Fereydouni Balangani * Department of Medical Biology, Faculty of Natural Sciences, Paris Lodron University of Salzburg, Salzburg, Austria |
| Abstract |
| Abstract Background and Aim: Hebbian plasticity, known as the principle that “cells that activate simultaneously connect,” is essential for learning, memory, and emotional processing. Recent developments indicate that non-invasive brain stimulation (NIBS), especially when targeted at multiple areas, can affect Hebbian processes and impact widespread cognitive and emotional networks. This systematic review seeks to investigate the impact of multi-site NIBS protocols on Hebbian plasticity and their significance for cognitive and affective functions in both healthy individuals and clinical populations. Methods: A thorough literature review was performed utilizing databases such as Web of Science, PubMed, ScienceDirect, and Scopus for studies published from 2015 to the current date. Studies were eligible if they featured multi-site NIBS (e.g., rTMS, tDCS) aimed at cognitive and/or emotional brain networks, with results pertinent to synaptic plasticity, cognition, or emotion. Screening and selection adhered to PRISMA guidelines, while data on stimulation parameters, targeted areas, and results were gathered and synthesized. Results: The examined research indicates that multi-site NIBS may improve or revive Hebbian-like plasticity by coordinating or altering activity among linked brain areas. Focused stimulation of prefrontal, parietal, and limbic regions resulted in enhancements in cognitive functions like attention and working memory, alongside emotional regulation. Multi-site methods proved to be more successful than single-site stimulation in activating functional networks and generating lasting neuroplastic changes. Nonetheless, differences in study designs and stimulation protocols continue to pose a limitation. Conclusion: Multi-site NIBS shows potential for influencing Hebbian plasticity in cognitive and emotional networks. Additional studies are required to improve protocols and elucidate mechanisms for clinical use. |
| Keywords |
| Hebbian plasticity, Non-invasive brain stimulation, Multi-site stimulation, Cognitive networks, Affective regulation |
| Status: Accepted |
