| Synergistic Effects of Curcumin, Allicin, and Propolis in Eradicating Helicobacter pylori and Preventing Precancerous Gastric Lesions Through a Translational Approach |
| Paper ID : 1260-IGA |
| Authors |
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InnoSci Hub * InnoSci Hub Team |
| Abstract |
| Background and Aim: Helicobacter pylori is a primary cause of chronic gastritis, gastric ulcers, and gastric cancer. Rising resistance to standard antibiotic treatments, such as triple therapy, highlights the need for safer and more effective alternatives. This study investigates the synergistic effects of curcumin, allicin, and propolis on H. pylori elimination and inhibition of inflammation and cancer-related pathways. Methods: In vitro assessments included minimum inhibitory concentration (MIC) tests and bacterial adhesion assays using AGS gastric epithelial cells. In vivo experiments involved mice infected with H. pylori, treated with the three-compound formulation. Inflammatory markers (IL-8 and TNF-α), histopathological changes, and expression levels of CagA, NF-κB, and COX-2 were evaluated. Results: All compounds demonstrated strong anti-H. pylori activity, with MIC values below 0.1 mg/mL. Propolis reduced bacterial adhesion by 95 percent and suppressed CagA secretion by 72 percent. In vivo treatment reduced gastric inflammation by 65 percent and intestinal metaplasia by 50 percent. Antioxidant activity increased by 30 percent. In a related human trial, the curcumin-garlic combination achieved an 85 percent suppression rate and a 60 percent reduction in dysplastic lesions, along with a 45 percent decrease in NF-κB and COX-2 expression. Conclusion: The curcumin-allicin-propolis combination shows strong potential as a natural therapeutic strategy against H. pylori. Its antimicrobial, anti-inflammatory, and chemopreventive effects warrant further clinical evaluation, especially in populations where antibiotic resistance is prevalent. |
| Keywords |
| Helicobacter pylori, Herbal compounds, Curcumin-Allicin-Propolis, Anti-bacterial resistance, Gastric cancer, Gastric ulcers |
| Status: Accepted |
