| Circulating Inflammatory Mediators in COVID-19-Affected Pregnancies: A Retrospective Evaluation of D-dimer ,ferritin and CRP Dynamics |
| Paper ID : 1253-IGA |
| Authors |
|
Vera Beca * University Hospital of Obstetrics and Gynecology ‘Queen Geraldine’, Tirana, Albania |
| Abstract |
| Background and Aim: The COVID-19 pandemic has posed significant challenges to healthcare systems globally. In particular, the impact of SARS-CoV-2 infection on pregnant individuals remains insufficiently characterized, with considerable uncertainty surrounding the prognostic value of inflammatory biomarkers in this population. This study examined the levels of three biomarkers—D-dimer, C-reactive protein (CRP), and ferritin—measured at the time of hospital admission in pregnant women with COVID-19, and evaluated their association with disease severity and clinical outcomes Materials and Methods: This retrospective study included pregnant women hospitalized with confirmed SARS-CoV-2 infection between January 2020 and December 2021,and admitted to the hospital due to COVID-19-related complications, such as respiratory distress, preeclampsia, or other severe symptoms. Additional criteria included complete medical and pregnancy outcomes. Results: The study included 83 pregnant women confirmed with COVID-19. Among them, 42% developed severe illness requiring admission to the intensive care unit (ICU), and 7% required mechanical ventilation. Biomarker analysis revealed significantly elevated concentrations of D-dimer ferritin and CPR with a p value ≤ 0.0001), particularly among patients admitted to the ICU, suggesting a correlation between heightened inflammatory response and disease severity Conclusion: Our study is based on data collected from the country’s main hospitals, including ‘Queen Geraldine’ Hospital ,which manages the highest volume of complicated pregnancy cases, particularly during the COVID-19 pandemic. C-reactive protein (CRP) demonstrated the most significant variation among inflammatory biomarkers during the course of COVID-19 in obstetric patients, supporting its utility as a valuable marker for monitoring disease progression. Additionally, ferritin and D-dimer appeared to serve as important prognostic indicators, particularly in patients requiring intensive care unit (ICU) admission |
| Keywords |
| COVID-19; pregnant women; Inflammatory biomarkers |
| Status: Accepted |
