| Pharmacological potentials of Nigella sativa: A narrative review on its medical applications and active compounds |
| Paper ID : 1247-IGA |
| Authors |
|
Rrahman Ferizi * Rrahman Ferizi, University of Prishtina, Faculty of Medicine, Prishtina, Kosovo |
| Abstract |
| Background and Aim: Black cumin or Nigella sativa has long been used in many cultures to treat a variety of diseases. Its main bioactive component, thymoquinone, is largely responsible for the wide range of biological activities demonstrated in recent pharmacological studies. The aim of this review is to provide a summary of currently available information on the therapeutic potential and mechanism of action of Nigella sativa in the treatment and prevention of chronic and viral diseases. Materials and Method: This report includes a thorough analysis of experimental, preclinical, and clinical research published in peer-reviewed journals. We searched databases such as ScienceDirect and PubMed to find research on thymoquinone or Nigella sativa. Studies evaluating antibacterial, hypoglycemic, cardioprotective, anti-inflammatory and antioxidant properties are highlighted. Results: Nigella sativa has shown significant pharmacological activity in a number of animal models. Neutralization of reactive oxygen species and increase in protective enzymes are associated with its antioxidant properties. Anti-inflammatory effects are observed by inhibiting pro-inflammatory cytokines. Clinical studies have shown favorable modulation of lipid profiles, antibacterial activity against a wide range of microorganisms, improved glycemic control in type 2 diabetes and protective effects on liver and kidney function. Conclusion: With many health benefits, Nigella sativa is a useful natural medicine. Although further randomized controlled studies are needed to confirm these results and establish uniform dosing procedures, its use in complementary medicine appears promising. |
| Keywords |
| Nigella sativa, thymoquinone, antioxidant, anti-inflammatory, diabetes, cardiovascular health, phytotherapy, traditional medicine |
| Status: Accepted |
