| Organoid-Based Disease Modeling and Drug Screening Using Stem Cells |
| Paper ID : 1242-IGA |
| Authors |
|
Piruz Shadbash * Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences |
| Abstract |
| Background and Aim: Organoids derived from stem cells have revolutionized biomedical research by providing physiologically relevant models for studying human diseases and drug responses. Unlike traditional two-dimensional (2D) cell cultures and animal models, organoids better replicate human tissue complexity, making them valuable tools in disease modeling, drug screening, and personalized medicine. This review explores the applications of organoids in cancer research, neurodegenerative diseases, and infectious disease studies. Furthermore, it discusses future advancements, such as CRISPR-based gene editing, high-throughput screening, and AI-driven analytics, that will enhance the effectiveness of organoid-based research. Methods: We conducted a review using keywords such as " Organoids, Disease Modeling, Drug Screening " including PubMed, Google Scholar, and Web of Science. Relevant studies were selected based on clearly defined inclusion and exclusion criteria. The chosen articles were evaluated by reviewing their titles, abstracts, methodologies, and results. The key findings from these studies are summarized in this review. Results: The field of organoid research continues to evolve, with several promising advancements on the horizon. These include gene editing technologies such as CRISPR-Cas9, organoid-on-a-chip systems, and the integration of artificial intelligence (AI) for predictive modeling. However, challenges such as vascularization, immune system incorporation, and standardization of culture methods remain critical hurdles. Conclusion: Organoids have emerged as transformative tools for disease modeling, drug discovery, and personalized medicine. Their ability to closely mimic human tissues makes them superior to traditional models. Despite existing challenges, advances in genetic engineering, biofabrication, and AI-driven automation are expected to enhance the utility of organoids in translational medicine. |
| Keywords |
| Organoids, Disease Modeling, Drug Screening |
| Status: Accepted |
