| In vitro Anticancer Properties of Ganoderma lucidum: A Mini-Review |
| Paper ID : 1218-IGA |
| Authors |
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zeınab moballeghı * phd Candidate Department of Biology Factuly of Scineces Azad University of Hamedan |
| Abstract |
| Background and Aim: Ganoderma lucidum (Reishi), a medicinal mushroom used in traditional medicine, has gained scientific attention for its potential anticancer properties. Bioactive compounds such as polysaccharides, triterpenoids, and ganoderic acids have been reported to exhibit cytotoxic effects against various cancer cell lines. This mini-review explores the in vitro anticancer potential of G. lucidum, focusing on its mechanisms of action, including apoptosis induction, immune modulation, and inhibition of cancer cell proliferation. Method: A systematic review of recent in vitro studies was conducted using databases such as PubMed, Scopus, and Web of Science. Research articles investigating the cytotoxic effects of G. lucidum extracts and its bioactive constituents on different cancer cell lines were analyzed. Results: In vitro studies have demonstrated that G. lucidum exhibits significant anticancer activity through multiple pathways, including apoptosis induction via mitochondrial and death receptor pathways, inhibition of angiogenesis and metastasis, and enhancement of immune response against cancer cells. Triterpenoids and polysaccharides have been identified as key contributors to these effects. However, variations in extraction methods, concentrations, and cell line responses highlight the need for standardized studies. Conclusion: Ganoderma lucidum holds promise as a natural anticancer agent, with in vitro evidence supporting its cytotoxic and immunomodulatory effects. Further research, including clinical trials, is necessary to validate its efficacy and therapeutic potential in cancer treatment. |
| Keywords |
| Keywords: Ganoderma lucidum, anticancer, apoptosis, triterpenoids, polysaccharides, in vitro, immune modulation. |
| Status: Accepted |
