| Association Between the Genetic Polymorphism of Quinone Oxidoreductase 1 (NQO1) and Colorectal Cancer Incidence: A Case-Control Study and Meta-Analysis. |
| Paper ID : 1211-IGA |
| Authors |
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Imen Kallel *1, Moez Hamdani2, Dhouha Jamai3, Saoussen Mekrazi4, Abdelmajid Khabir2 1University of Sfax Faculty of Sciences of Sfax 2Department of Anatomopathology and Cytology - Habib BOURGUIBA Hospital, Medenine, Tunisia 3Research Laboratory of Bioresources, Integrative Biology and Valorization LR14ES06, Higher Institute of Biotechnology of Monastir, University of Monastir, Avenue Tahar Hadded, BP 74, 5000 Monastir, Tunisia. 4Research Laboratory of Environmental Toxicology-Microbiology and Health (LR17ES06), Faculty of Sciences, University of Sfax,3000 Sfax, Tunisia |
| Abstract |
| Background and Aim: Colorectal cancer (CCR), a major public health issue representing about 10% of all cancers, is the third most common cancer in men and the second in women worldwide. The enzyme NQO1 plays a crucial role in metabolizing quinones and detoxifying potentially carcinogenic compounds. The most studied polymorphism in the NQO1 gene is C609T. Due to NQO1's antitumor properties, exploring its association with colorectal cancer risk is crucial. This study investigated the link between the NQO1 C609T polymorphism and occurrence of colorectal cancer in the Tunisian population. A NQO1 C609T meta-analysis was also performed. Materials and Methods: This was a retrospective cross-sectional study of control cases, with a sample of 201 participants, including 102 controls and 99 patients. The meta-analysis included 10 case-control studies with 3498 patients with CRC and 4347 controls taking into account our study. Results: The CT genotype was associated with a higher risk of CRC with a total Odds Ratio [95%CI] of 1.14 [1.03; 1.26]. The study of the distribution of C609T polymorphism between patients and controls showed no significant difference. The study of the genotype distribution of the NQO1 enzyme showed that this gene was homozygous mutated (CC) in 19.2% of patients and 11.8% of controls. It was heterozygous (CT) in 29.3% and 24.5% in patients and controls, respectively. The T-allelic frequency is 0.240 for controls and 0.338 for patients. The NQO1 PNS was significantly correlated with smoking status and age in controls. The correlation study between NQO1 PNS and the clinical-pathological parameters showed a significant correlation with age, tumor topography, ganglion metastases and distant metastasis. Conclusion: This study emphasis the link between the NQO1 C609T polymorphism and colorectal cancer (CRC) in Tunisian patients. The CT genotype showed a slightly higher CRC risk. Further research is needed to clarify its role in CRC. |
| Keywords |
| Keywords: Colorectal Cancer, Genetic Polymorphism, Quinone Oxidoreductase 1 (NQO1), Meta-Analysis |
| Status: Accepted |
