| A review on Development of an Innovative High-throughput Multi-drug Screening Assay at IRST Meldola-Forli: Insights from Zebrafish Models of Cancer |
| Paper ID : 1205-IGA |
| Authors |
|
Seyedeh Narges Kheirkhah * Department of Pharmacy,Faculty of Pharmacy,University of Bologna |
| Abstract |
| Background and Aim: Zebrafish (Danio rerio) have emerged as valuable non-mammalian vertebrate models in cancer research due to their evolutionary conservation with humans, cost-effective maintenance, and transparency, which facilitates real-time visualization of tumor growth. This review aims to assess the application of zebrafish models in the development of high-throughput multi-drug screening assays, with a focus on recent advancements at IRST Meldola-Forli. Methods: A comprehensive literature review was conducted using databases such as Google Scholar, Web of Science, ScienceDirect, and PubMed. The inclusion criteria encompassed English-language peer-reviewed articles published between 2015 and 2025. Keywords used in the search included 'Zebrafish', 'Cancer Models', 'Drug Screening', 'High-throughput', 'Multi-drug Assay', and 'Personalized Medicine'. Results: The review identified numerous studies highlighting the utility of zebrafish in cancer research, particularly for high-throughput screening and personalized medicine. Zebrafish models demonstrate significant advantages in drug screening due to their scalability and real-time imaging capabilities. IRST Meldola-Forli has contributed significantly to the development of innovative assays using zebrafish. Discussion: Despite the numerous benefits, zebrafish models also present challenges, including physiological differences from humans and the limited availability of zebrafish-specific reagents. Integrating zebrafish models with mammalian studies is recommended to enhance translational research. |
| Keywords |
| Zebrafish, Cancer Models, Drug Screening, Multi-drug Assay, High-throughput, IRST Meldola-Forli, Personalized Medicine |
| Status: Accepted |
