| Exploring the Impact of Samaritan on Infertility: Implications for Spermatogenesis and Hormonal Regulation |
| Paper ID : 1192-IGA |
| Authors |
|
Helia Fathi * Department of Cognitive Sciences, School of Converging Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran |
| Abstract |
| Background and Aim: Sumatriptan, a selective serotonin receptor agonist (5-HT1B/1D), not only affects the nervous system but also plays a role in regulating testicular function by modulating serotonin pathways. However, studies examining the effects of sumatriptan on male reproductive system remain limited. Therefore, this study aims to evaluate the impact of sumatriptan on spermatogenesis and testosterone regulation in male NMRI mice. Materials and Methods: In this experimental study, 24 male NMRI mice, weighing between 25-35 grams, were randomly divided into four groups: control (normal conditions), sham (receiving only the drug solvent), low-dose sumatriptan (1.5 mg/kg), and high-dose sumatriptan (5.5 mg/kg). The drug was administered daily via oral gavage for 22 days, after which samples were collected for biochemical and histological analysis. Results: Serum testosterone levels showed a significant increase in the sumatriptan-treated groups compared to the control. Moreover, sperm count was significantly higher in the high-dose sumatriptan group when compared to the control group, indicating a dose-dependent effect of sumatriptan on spermatogenesis. Conclusion: These results suggest that sumatriptan may have a positive effect on male reproductive health by enhancing testosterone levels and sperm production, particularly at higher doses. Given its impact on spermatogenesis, sumatriptan could potentially be explored as a therapeutic option for addressing certain aspects of male infertility, although further studies are needed to fully understand its role in fertility regulation. |
| Keywords |
| Sumatriptan, Testosterone, Spermatogenesis, Male infertility |
| Status: Accepted |
