| Mesenchymal Stem Cells and Their Genetic Influence on Wound Healing: A Mini Review |
| Paper ID : 1186-IGA |
| Authors |
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Rezvaneh Jahangiri * Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran |
| Abstract |
| Background and Aim: Mesenchymal stem cells (MSCs) have gained attention for their regenerative properties in wound healing. They contribute to tissue repair through mechanisms such as cell proliferation, migration, immune modulation, and angiogenesis. Recent studies suggest that MSCs also exert genetic influence on wound healing by regulating key molecular pathways. This mini-review aims to explore the role of MSCs in wound healing, with a focus on their genetic interactions and therapeutic potential. Methods: A systematic literature search was conducted using PubMed, Scopus, and Google Scholar. Studies published in English from 2015 onward were included, using keywords such as "mesenchymal stem cells," "wound healing," "genetic influence," "angiogenesis," and "immune modulation." Only peer-reviewed studies discussing MSCs’ genetic role in wound healing were considered. Results: MSCs promote wound healing by enhancing fibroblast and keratinocyte proliferation, reducing oxidative stress, and stimulating angiogenesis. Genetic modifications of MSCs, such as overexpression of growth factors, further enhance their regenerative potential. Additionally, environmental factors like hypoxia influence MSC efficacy, altering gene expression patterns that support tissue repair. Advances in MSC-based therapies, including genetic engineering and scaffold-based delivery systems, have shown potential in accelerating wound healing and improving tissue regeneration. Conclusion: MSCs play a critical role in wound healing by modulating genetic pathways that regulate inflammation, cell migration, and tissue regeneration. Their therapeutic potential can be further enhanced through genetic modifications and optimized delivery methods. Future research should focus on refining MSC-based therapies for clinical applications in regenerative medicine. |
| Keywords |
| Mesenchyme stem cell, Genetic influence, Wound healing |
| Status: Accepted |
