| Genetic Factors in Leukemia: A Mini Review |
| Paper ID : 1185-IGA |
| Authors |
|
Rezvaneh Jahangiri * Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran |
| Abstract |
| Background and Aim: Leukemia is a diverse group of hematologic malignancies that result from genetic mutations disrupting normal blood cell development. Understanding the genetic basis of leukemia can inform both prognosis and treatment strategies. The genetic landscape of leukemia involves a wide range of mutations, chromosomal abnormalities, and epigenetic changes. Methods: A review of relevant literature was conducted by searching databases such as PubMed, Scopus, and Google Scholar. Articles from 2015 onwards written in English were included. Keywords such as “genetic factors in leukemia,” “genetic mutations in leukemia,” “chromosomal translocations,” and “leukemia prognosis” were used to gather studies. Results: Studies revealed that various genetic mutations contribute to leukemia development. Chromosomal translocations such as t(9;22) in chronic myelogenous leukemia and mutations in the TP53 gene are well-documented. Mutations in genes related to the cell cycle, apoptosis, and DNA repair also contribute to leukemia progression. Environmental factors, such as exposure to chemicals and radiation, interact with genetic predispositions to increase leukemia risk. Conclusion: Genetic factors play a pivotal role in the pathogenesis of leukemia. Further research into the genetic mutations and pathways involved in leukemia will improve early diagnosis, prognostic predictions, and the development of personalized therapeutic approaches, thereby enhancing patient outcomes. |
| Keywords |
| Leukemia, Genetic factors, Mutations, Chromosomal translocations |
| Status: Accepted |
