| CADMIUM-INDUCED HEPATO-RENAL TOXICITY IN RATS: PROTECTION BY CINNAMIC ACID VIA ANTIOXIDATIVE PATHWAY |
| Paper ID : 1182-IGA |
| Authors |
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OLUBUKOLA OYEBIMPE AGBOOLA *1, Adepeju Aberuagba2, Ige Francis Olaoye3 1McPherson University, Seriki Sotayo Ogun State, Nigeria 2Department of Biochemistry and Molecular Biology, McPherson University 3Department of Biochemistry and Molecular Biology McPherson University Seriki Sotayo Km 96, Abeokuta, Ogun State |
| Abstract |
| Objective(s): Cadmium chloride (CdCl2), a highly toxic compound, poses significant risks to human health especially oxidative injury. The use of antioxidants such as Cinnamic acid has been used in the treatment of oxidative stress. Hence, this study investigates the ameliorative effects of Cinnamic acid on Cadmium chloride–induced hepato-renal injury. Materials and Methods: Thirty male Wistar rats, divided into six groups (n=5), were treated with Corn oil (control), CdCl2, CdCl2 + CA (50 mg/kg), CdCl2 + CA (100 mg/kg), CA only (50 mg/kg) and (100 mg/kg). Rats were pretreated with CA (p.o) for 7 days and challenged with intraperitoneal injection of two doses of CdCl2 (1.5 mg/kg) at the last 72 hours. Results: Administration of CdCl2 caused a significant (p<0.05) increase in the levels of serum Urea, Creatinine and renal lipid peroxidation (LPO) by 79%, 25% and 29%, respectively when compared with the control. However, the activity of renal superoxide dismutase and the level of renal reduced glutathione were significantly (p<0.05) decreased by 50% and 26%, respectively relative to the control. CdCl2 also significantly increased the activities of serum AST and levels of liver LPO by 76% and 71%, respectively while the activity of SOD in the liver was insignificantly (p>0.05) decreased. Interestingly, pre-treatment with cadmium chloride significantly reduced the serum indices and restored the antioxidant parameters in the tissues close to normal. Conclusion: Cinnamic acid ameliorates Cadmium chloride-induced kidney and liver dysfunction via antioxidative pathway. |
| Keywords |
| Cadmium chloride, Cinnamic Acid, Oxidative injury, Antioxidant |
| Status: Accepted |
