| Navigating the Double-Edged Sword: An Integrative Review of Nanoparticles in Drug Delivery and Their Risks |
| Paper ID : 1177-IGA |
| Authors |
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Atefeh Hasanli * Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran |
| Abstract |
| Abstract: Back ground and Aim: To examine the applications of nanoparticles in drug delivery systems, highlighting both their benefits and risks.To address the challenges in evaluating the safety of nanoparticles, including their potential long-term effects on human health and the environment. Method: This is an integrative review that explores different types of nanoparticle delivery systems, such as liposomes, micelles, chitosan, and synthetic dendrimers1. It also discusses drug encapsulation mechanisms, release profiles, and tissue-specific delivery capabilities. Findings: Nanoparticles offer the potential to improve the efficacy, characteristics, and bioavailability of therapeutic agents1. Their small size, large surface area, and customizable surface properties enable them to overcome biological barriers and target specific cells and tissues. However, these unique characteristics also present potential risks, including toxicity, immunogenicity, and environmental concerns. Conclusion: Th review emphasizes the necessity of rigorous testing, standardization, and the development of regulatory frameworks to mitigate risks while maximizing the therapeutic potential of nanoparticles. This comprehensive analysis underscores the dual nature of nanoparticle technologies and the importance of a balanced risk-benefit assessment in their clinical applications. |
| Keywords |
| : Nanoparticles , Drug delivery, Target tissues, Toxicity, Liposomes, Polymeric nanoparticles. |
| Status: Accepted |
