| Nanotechnology in Oncology: Therapeutic Breakthroughs and the Risk Landscape |
| Paper ID : 1175-IGA |
| Authors |
|
Atefeh Hasanli * Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran |
| Abstract |
| Abstract: Back ground and Aim: To examine recent advances in the application of nanotechnology to oncology, highlighting therapeutic breakthroughs. This review aims to provide a comprehensive overview of the current state of cancer nanotherapeutics while critically evaluating the potential risks and challenges associated with their clinical translation. Methods: A systematic review of the literature was conducted, focusing on preclinical and clinical studies that assess the efficacy and safety of nanoparticle-based cancer therapies. The analysis included FDA-approved cancer drugs and promising candidates currently in clinical trials. Findings: Nanotechnology has facilitated the development of several FDA-approved cancer drugs, demonstrating improved pharmacokinetic profiles and enhanced drug accumulation in tumors. These advancements have resulted in reduced side effects compared to conventional treatments. Discussion: The review addresses potential risks, such as off-target effects and immunogenicity, emphasizing the importance of continued research to optimize the design and development of cancer nanotherapeutics. It highlights the need for rigorous preclinical and clinical evaluation to ensure safe and effective applications in oncology. Overall, while nanotechnology presents significant opportunities for advancing cancer treatment, careful consideration of associated risks is essential for successful clinical translation. Further research and innovation are necessary to harness the full potential of nanotherapeutics, paving the way for more effective and personalized cancer therapies This synthesis encapsulates the critical aspects of recent developments in nanotechnology for oncology, focusing on breakthroughs while acknowledging challenges that must be addressed for future success. |
| Keywords |
| : Nanotechnology, Oncology, Cancer Therapy, Drug Delivery, Targeting, Nanoparticles, Gene Therapy, FDA-Approved Drugs. |
| Status: Accepted |
