| Molecular Basis of Silver Nanoparticles in Breast Cancer Cells |
| Paper ID : 1146-IGA |
| Authors |
|
Vida Ghaemi *1, Minoo Iranshahi2 1Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran 2Community Pharmacy, München, Bayern, Deutschland |
| Abstract |
| Background and Aim: Silver nanoparticles (AgNPs) have been shown to exert anticancer effects on cancer cells including breast cancer cells; however, the molecular basis of AgNPs action on breast cancer cells is a challenging topic. The aim of this study was to review the molecular basis of AgNPs against breast cancer cell. Method: Papers published in prestigious academic databases such as PubMed, Scopus, and Web of Science were reviewed and the papers published between 2000 and 2024 were included. Experimental and clinical studies focusing on the molecular basis of AGNPs in breast cancer cells were included. Results: Several studies have investigated the mechanisms of action of AgNPs in breast cancer cells. AgNPs encapsulating 5-fluorouracil have been shown to increase the synergistic induction of apoptosis in cancer cells including breast cancer cells. Treatment with AgNPs induces caspase 9-dependent cell death in breast cancer MCF7 and MDA-MB-231 cells. AgNPs can induce apoptosis and/or autophagy activation SKBR3 in breast cancer cells. AgNPs may induce cell death in MCF-7 cell lines through Reactive Oxygen Species (ROS)-mediated apoptosis. Green synthesized from Zizyphus mauritiana fruit extract has antiproliferative effects on MCF-7 cells. AgNPs can induce apoptotic cell death in MCF-7 breast cancer cells by green-synthesized AgNPs through ROS generation and activation of caspase 3 and 9 enzyme activities. AgNPs influences mitochondrial and ER homeostasis in human breast cancer cells, affecting cell fate. Conclusion: Molecular basis of anticancer effects of AgNPs in breast cancer cells is mediated partly by apoptosis and ROS-mediated cytotoxicity in breast cancer cells |
| Keywords |
| Silver nanoparticles, Breast cancer, Apoptosis, Reactive oxygen species |
| Status: Accepted |
