| Association of Carotenoids with Breast Cancer |
| Paper ID : 1145-IGA |
| Authors |
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Vida Ghaemi *1, Minoo Iranshahi2 1Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran 2Community Pharmacy, München, Bayern, Deutschland |
| Abstract |
| Background and Aim: Breast cancer has been reported to increase globally imposing a public health in both developing and developed societies. The association of carotenoids and cancer development has been demonstrated in a number of clinical, in vivo, and in vitro studies. In this study we reviewed the relationship between carotenoids and breast cancer. Method: A review of the literature was conducted using databases such as PubMed, Scopus, and Web of Science, covering studies published between 2000 and 2024. Experimental and clinical studies focusing on association of carotenoids and breast cancer were included. Mechanistic studies exploring the biological action of carotenoids on cancer cells were also reviewed. Results: Studies have found that circulating carotenoids may be linked to breast cancer risk. It has been suggested that high consumption of carotenoids could reduce the risk of premenopausal breast cancer. Significant associations have been reported between plasma carotenoids, retinol, tocopherols, and postmenopausal breast cancer risk. An inverse association has been observed between plasma concentrations of β-cryptoxanthin and β-carotene with overall and breast cancer risk. We have shown that deinoxanthin, a carotenoid extract, can induce apoptosis in breast cancer cells by decreasing of anti-apoptotic BCL2 gene expression level and also increasing of BAX gene expression levels. Conclusion: Overall, the findings of experimental and clinical studies reveal the potential role of carotenoids in breast cancer risk, with some studies suggesting a protective effect. Further research is required to reveal the exact mechanism behind the relationship between carotenoids and breast cancer |
| Keywords |
| Carotenoids, Breast cancer, Antioxidants, Cancer prevention |
| Status: Accepted |
