| Transgenic Animals as Models for Studying Human Physiological Diseases: Implications for Biotechnology |
| Paper ID : 1129-IGA |
| Authors |
|
Azin Azadpour * Department of Biotechnology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran |
| Abstract |
| Background and Aim: Transgenic animals have emerged as invaluable tools for studying diseases, providing insights into disease mechanisms, progression, and potential therapeutic interventions. This review aims to evaluate the current applications of transgenic animal models in understanding diseases and to highlight the implications of these advancements for biotechnology. Materials and Methods: A comprehensive literature search was conducted using key terms such as “transgenic animals,” “physiological diseases,” “biotechnology,” “animal models,” and “gene editing.” Databases including Google Scholar, PubMed, Clarivate, and ScienceDirect were utilized to gather relevant peer-reviewed articles, reviews, and case studies published within the last two decades. The selected studies were analyzed to extract data on the development, characterization, and applications of various transgenic models in disease research. Results: The review identifies a diverse array of transgenic models that mimic diseases, including cardiovascular diseases, diabetes, neurodegenerative disorders, and metabolic syndromes. Key findings illustrate how these models have contributed to a better understanding of disease mechanisms, facilitated the testing of new therapies, and provided platforms for personalized medicine. Notably, advancements in CRISPR-Cas9 technology have enhanced the precision and efficiency of creating transgenic models, further expanding their utility in research. Conclusion: Transgenic animals represent a critical component of biotechnological research in disease. Their ability to replicate complex human diseases allows for in-depth studies that can lead to innovative therapeutic strategies. As biotechnology continues to evolve, the integration of transgenic models in research is expected to play an increasingly vital role in bridging the gap between laboratory findings and clinical applications. |
| Keywords |
| Transgenic animals, Diseases, Biotechnology, Animal models, CRISPR-Cas9 |
| Status: Accepted |
